Title: Chronic inflammation-oral cancer correlations

Neoplasms of the oral cavity represent a public health problem and represent the sixteenth most common cancer worldwide. Currently, there are no sensitive biomarkers for the early detection of this cancer present, there are no sensitive biomarkers for the early detection of this cancer. Considering the multitude of factors associated with the occurrence, development and progression of cancer, as well as their varied involvement and interconnection within the same cancer, it is currently difficult to establish a unified protocol for both early detection and diagnosis and treatment of cancer. Therefore, it is essential to identify patients at risk of malignant transformation. Several studies have examined the role of chronic inflammation in carcinogenesis, highlighting their involvement in the development of various types of cancer, such as liver, gastric, bladder, cervical, and thyroid cancer. Although the oral mucosa is constantly exposed to trauma that can induce chronic inflammation, there are fewer studies investigating the relationship between chronic inflammatory lesions and oral neoplasms. Currently, there is a continuing need to identify the connecting factors that can predict the progression of the neoplasm.